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Updated: May 20, 2026

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Shigella flexneri エフェクタ OspI は UBC13 をデアミダートし,炎症反応を抑制する

Takahito Sanada1, Minsoo Kim, Hitomi Mimuro

  • 1Department of Infectious Disease Control, International Research Center for Infectious Diseases, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.

Nature
|March 13, 2012
PubMed
まとめ

Shigella flexneriは,そのエフェクタ OspI を使用して,UBC13 をデミダ化することによって宿主の炎症反応を抑制し,それによって TRAF6 信号伝達を阻害し,早期感染検出を防止します.

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