癌治療を治療法に変換する:感染症から学ぶこと
Michael S Glickman1, Charles L Sawyers
1Infectious Diseases Service and Immunology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. glickmam@mskcc.org
Cell
|March 20, 2012
まとめ
癌の薬剤耐性は,感染症の課題を反映しています. 治療の組み合わせと持続的な細胞を標的とした治療は,治療の失敗を克服し,両方の分野での再発を防ぐための鍵です.
科学分野:
- 腫瘍学 腫瘍学
- 感染症 感染症は感染症です.
- 薬理学 薬理学とは
背景:
- ガン治療薬の開発は標的型療法へと移行しているが,一時的な反応と耐薬性は依然として大きな課題である.
- 薬剤耐性は,がんおよび感染症の両方の治療失敗の主な原因であり,新しい治療戦略を必要とします.
- 感染症における耐性メカニズムの理解は,がん治療を改善するための貴重な洞察を提供します.
研究 の 目的:
- 癌および感染症における薬剤耐性メカニズムを比較および対比する.
- ウイルスおよび細菌感染症に対して使用される戦略が,がん治療にどのように役立つかを探求する.
- 薬剤耐性持続細胞と腫瘍発起細胞を排除し,再発を防ぐためのアプローチを特定する.
主な方法:
- 癌および感染症における抵抗機構の比較分析.
- HIVと結核を克服するための治療戦略のレビュー.
- シナゲティック・コンビネーション・セラピーの検討と,持続性/幹細胞の標的化について.
主要な成果:
- 癌と感染症は,薬剤耐性の発達に類似した課題を共有しています.
- コンビネーションセラピーは,両方の分野における初期治療応答の最大化に不可欠です.
- 薬剤耐性持続細胞 (感染症) と腫瘍発症/幹細胞 (がん) をターゲットにすることは,長期的な寛解に不可欠です.
結論:
- 感染症研究から学んだ教訓,特に組み合わせ治療と持続性のある細胞を標的とした治療について,より合理的ながん治療を導くことができます.
- 薬剤耐性持続性および腫瘍発起細胞を排除する薬剤の開発は,癌および感染症の両方で遅い再発を予防し,治療期間を短縮するために重要です.
- 薬剤耐性に対抗するための統合されたアプローチは,さまざまな分野にまたがって,患者の治療結果を改善することを約束しています.
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