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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Introduction to Nuclear Reprogramming01:14

Introduction to Nuclear Reprogramming

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Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
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Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

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Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
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Updated: May 5, 2026

Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells
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再生医療のための細胞アイデンティティの再プログラミング

Anne B C Cherry1, George Q Daley

  • 1Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Children's Hospital Boston and Dana Farber Cancer Institute, Boston, MA 02115, USA.

Cell
|March 20, 2012
PubMed
まとめ
この要約は機械生成です。

細胞の再プログラミングは,細胞のアイデンティティを変換し,強力な患者特有の疾患モデルを作成することができます. 高浸透性の遺伝疾患は,これらの新しい幹細胞モデルにとって最も有益です.

さらに関連する動画

Epigenetic Conversion as a Safe and Simple Method to Obtain Insulin-secreting Cells from Adult Skin Fibroblasts
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Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method
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13:58

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Published on: July 29, 2015

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Epigenetic Conversion as a Safe and Simple Method to Obtain Insulin-secreting Cells from Adult Skin Fibroblasts
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Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method
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科学分野:

  • バイオメディカル研究
  • 幹細胞生物学 幹細胞生物学とは
  • 細胞を再プログラムする.

背景:

  • 細胞の発達は通常,制限された細胞運命を導きます.
  • 細胞の再プログラミングは,一つの細胞のアイデンティティを別の細胞に変換することを可能にします.
  • この技術は,生物医学研究と疾患モデリングの有望な可能性を秘めています.

研究 の 目的:

  • 細胞再プログラミングを用いた患者特有の情報型疾患モデルに関する証拠をレビューする.
  • 生物医学における細胞再プログラミングの影響を議論する.
  • 再プログラミングが細胞の分化と再生医療の理解を向上させる方法を概説する.

主な方法:

  • 細胞の再プログラムと疾患モデリングに関する既存の証拠のレビュー.
  • 患者由来幹細胞モデルの情報性に影響を与える要因の分析.
  • 再プログラミングが細胞の分化と再生医療に与える影響に関する議論.

主要な成果:

  • 環境の影響と表遺伝子シグネチャは,再プログラム中にほとんど消去されます.
  • 強い遺伝的基盤と高い浸透性を持つ疾患の患者特有のモデルは,短期的に最も情報的である.
  • 細胞の再プログラミングは,細胞の微分化に関する理解と,細胞療法やin vivo再生の見通しを向上させています.

結論:

  • 細胞の再プログラミングは,患者特有の疾患モデルを作成するための強力なツールを提供します.
  • 高い浸透率を持つ遺伝子に基づく疾患のモデルは,短期的な研究にとって最も価値があります.
  • 再プログラミングは,基礎生物学に関する理解を深め,再生医療におけるイノベーションを推進します.