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開発と病気の表遺伝的景観における規制された騒音
Elisabet Pujadas1, Andrew P Feinberg
1Center for Epigenetics, Johns Hopkins University, 570 Rangos, 855 North Wolfe Street, Baltimore, MD 21205, USA.
Cell
|March 20, 2012
まとめ
エピゲノムは,騒音を制御し,発達や病気に影響を与えることによって,細胞の可塑性を調節します. このモデルは,細胞の運命へのコミットメントを説明し,がんの異質性に関する新しい洞察を提供します.
科学分野:
- エピジェネティクス エピジェネティクス
- 細胞生物学 細胞生物学
- 発達生物学 発達生物学について
- 病気のメカニズム 病気のメカニズム
背景:
- ストキャスティックノイズと非遺伝的異質性は,細胞行動に影響を与える重要な要因です.
- クロマチンのドメインは,病気で乱調され,発達中に再構成されることが知られている.
- 細胞の可塑性は,発達と病気における基本的なプロセスである.
研究 の 目的:
- エピゲノムがノイズを調節することによって細胞の可塑性を調節するモデルを提案する.
- 細胞の可塑性におけるクロマチンのドメインの役割を調査する.
- ワディントンのエピジェネティック・ランドスケープの数学的な枠組みを提示する.
主な方法:
- エピジェネティクスにおける過去と現在の観察の合成.
- ストキャスティックノイズと非遺伝的異質性の議論.
- エピジェネティック・ランドスケープの数学モデリング.
主要な成果:
- 提案されたモデルは,細胞運命を約束する過程で,表遺伝子組が相転換とチャネリングを容易にすることを示唆している.
- 異なるクロマチンのドメインが,細胞の可塑性の基礎となる可能性があります.
- エピジェネティック・ランドスケープのための数学的形式主義が提示されています.
結論:
- エピゲノムによる騒音の調節は,発達と疾患における細胞の可塑性にとって極めて重要です.
- 新しい枠組みは,病気のメカニズム,特にがんの異質性についての理解に影響を与える可能性があります.
- がんにおけるDNAメチル化と遺伝子発現の変動性の増加は,このモデルによって説明できる.
関連する概念動画
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