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助産生殖技術で受精した子供の全身的および肺血管機能障害
Urs Scherrer1, Stefano F Rimoldi, Emrush Rexhaj
1Swiss Cardiovascular Center Bern, University Hospital, Bern, Freiburgstrasse, BHH A 143, Bern, 3010, Switzerland. urs.scherrer2@insel.ch
Circulation
|March 22, 2012
まとめ
助産生殖技術 (ART) で受精した子供は,一般的な血管機能不全の兆候を示しています. これは,親の要因ではなく,ART手順そのものが,子孫の心血管健康に影響を与える可能性があることを示唆しています.
科学分野:
- 心血管生理学 心血管の生理学
- 生殖医学は,生殖器医学である.
- 小児の健康に関する小児保健
背景:
- 助産生殖技術 (ART) は,初期の胚の操作を含み,子孫に対する潜在的な長期的な健康影響に関する懸念を提起しています.
- 発達中の環境要因は,心血管疾患の感受性に影響します.
- 子孫の血管健康に対するARTの影響は,調査が必要です.
研究 の 目的:
- ART後に生まれた子供の全身的および肺血管機能をコントロールと比較して評価する.
- ARTの手続きが子孫の血管機能不全に寄与するかどうかを判断する.
主な方法:
- システム血管機能は,フローメディエートされた膨張,パルス波速度,および頸動脈内側介質の厚さによって評価される.
- 高地での肺動脈圧のドップラーエコーカルディオグラフィで評価された肺血管機能.
- 65人のARTで受精した子供と57人の対照子の比較.
主要な成果:
- ART児は,対照群と比較して,腕動脈の流動媒介の拡張が25%小さかった.
- ARTの子どもは,大動脈-股関節脈波の速度が著しく速く,大動脈の内側-中枢の厚さが大きかった.
- 静脈性肺動脈の圧力は,高地でのARTの子供では30%高かった.
結論:
- ARTで受精した健康な子供は,一般的な血管機能不全を示しています.
- 観察された血管機能障害は,親の要因ではなく,ART手順に関連しています.
- ARTに関連する血管リスクを理解し,軽減するためにさらなる研究が必要である.
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