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Updated: Apr 3, 2026

Harvesting and Cryo-cooling Crystals of Membrane Proteins Grown in Lipidic Mesophases for Structure Determination by Macromolecular Crystallography
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μ-オピオイド受容体の結晶構造は,モルフィナンのアンタゴニストと結合する

Aashish Manglik1, Andrew C Kruse, Tong Sun Kobilka

  • 1Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, USA.

Nature
|March 23, 2012
PubMed
まとめ

研究者はマウスのμ-オピオイド受容体 (μ-OR) の結晶構造を決定し,独特で大きな結合ポケットと二次元構造を明らかにしました. この発見は,痛みの改善と中毒治療の開発に役立ちます.

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