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Updated: May 23, 2026

Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale
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Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale

Published on: May 17, 2014

ラパミシン誘発のインスリン抵抗性は,mTORC2の損失によって媒介され,長寿から切り離されています

Dudley W Lamming1, Lan Ye, Pekka Katajisto

  • 1Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

Science (New York, N.Y.)
|March 31, 2012
PubMed
まとめ

ラパミシンはmTORC1を阻害することで寿命を延ばしますが,mTORC2.2を阻害することでグルコース耐性を低下させます. この研究は,mTORC2の障害がラパミシンを媒介することを明らかにしています.

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A Semi-Quantitative Drug Affinity Responsive Target Stability (DARTS) assay for studying Rapamycin/mTOR interaction05:28

A Semi-Quantitative Drug Affinity Responsive Target Stability (DARTS) assay for studying Rapamycin/mTOR interaction

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