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ホモディメア型ヘモグロビンの協同タンパク質構造ダイナミクスの直接観察は,ポンプ探査機によるX線溶液散射で100psから10msまでである

Kyung Hwan Kim1, Srinivasan Muniyappan, Key Young Oang

  • 1Center for Time-Resolved Diffraction, Department of Chemistry, Graduate School of Nanoscience & Technology (WCU), KAIST, Daejeon, 305-701, Republic of Korea.

Journal of the American Chemical Society
|April 13, 2012
PubMed
まとめ

この研究では,X線溶液分散を用いて,タンパク質の構造動態をリアルタイムで明らかにし,ヘモグロビン変異の3つの中間体を特定しました. 1つのサブユニットにおけるリガンド結合は,2つのサブユニットにおける結合の効果を反映し,タンパク質の機能に関する新しい洞察を提供します.

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