メタボライトプロファイリングは,ヒトにおける代謝リスクに関連する経路を特定します
Susan Cheng1, Eugene P Rhee, Martin G Larson
1Cardiology Division, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA.
Circulation
|April 13, 2012
まとめ
肥満のような代謝リスク要因は,特定の血液代謝産物と関連しています. グルタミン酸と比較してグルタミン酸がより高い値は,マウスモデルで示されているように,糖尿病と血圧のリスクを軽減する可能性があります.
科学分野:
- メタボロミクスとは
- 心血管疾患に関する研究
- 糖尿病研究研究 糖尿病研究
背景:
- メタボリックリスク要因は,糖尿病や心血管疾患に罹患しやすい個人に集まります.
- これらのクラスターの基礎となる生物学的メカニズムは十分に理解されていません.
研究 の 目的:
- 心臓代謝リスクに関連する代謝経路を特定する.
- 血代謝産物と心臓代謝リスク因子との関係を調査する.
主な方法:
- 液体クロマトグラフィー/質量スペクトロメトリーは,45のプラズマ代謝物質を測定する.
- フレミングハム心臓研究 (FHS) とマルメ・ダイエットとがん研究 (MDC) の分析.
- 心血管疾患と代謝疾患の実験モデルでの発見の尋問.
主要な成果:
- 分岐鎖アミノ酸,水害性アミノ酸,トリプトファンの分解産物,および核酸代謝産物に関連する代謝リスク要因.
- インスリン抵抗性は,グルタミン,グルタミン酸,およびグルタミンとグルタミン酸の比率と強く関連しています.
- 高グルタミン対グルタミン酸比は,FHSにおける糖尿病発生リスクの低下と関連しています.
- マウスのグルタミン投与は,グルコース耐性を改善し,血圧を下げました.
結論:
- 生化学的プロファイリングにより,代謝特性に関連した新種の循環代謝物質が特定されました.
- グルタミン酸に対する過剰グルタミン,外因的投与から,マウスでの代謝リスクの低下.
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