生細胞のデラミネーションは,上皮の成長を相殺し,組織の過密化を制限します
Eliana Marinari1, Aida Mehonic, Scott Curran
1Medical Research Council Laboratory of Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK.
Nature
|April 17, 2012
まとめ
皮質組織の成長は,新しい群集誘発細胞デラミネーションプロセスによってバランスをとります. このメカニズムは,細胞死とは異なり,組織の秩序を維持するのに役立ち,早期の癌発症に影響を与える可能性があります.
科学分野:
- 細胞生物学 細胞生物学
- 発達生物学 発達生物学について
- バイオフィジックス 生物物理学
背景:
- 皮質の発達にはバランスの取れた成長と細胞死が必要です.
- 組織の成長を制御し,解消を防止するメカニズム (例えば,腫瘍発生) は完全に理解されていません.
- 皮質組織成長の適切なフィードバック制御は,ホメオスタシスにとって極めて重要です.
研究 の 目的:
- 皮質組織の成長におけるフィードバック制御の新たなメカニズムを特定する.
- 成長バランスの取れるプロセスとして,混雑誘発の細胞デラミネーションを調査する.
- 組織発育と疾患における細胞デラミネーションの影響を理解する.
主な方法:
- Drosophila notumをモデルシステムとして利用した.
- 混雑によって引き起こされる細胞のデラミネーションが観察され,分析された.
- エピテリア力学のコンピューティングモデリングを採用した.
- アポトーシス媒介の細胞挤出による差別化されたデラミネーション.
主要な成果:
- エピテリア組織における群集誘発性細胞デラミネーションの新しいプロセスを特定しました.
- デラミネーションは,細胞の接合点と頂点領域の喪失を含み,細胞の挤出につながることを実証しました.
- このプロセスはアポトーシスとは機械的に異なっており,細胞死に先行することを示した.
- 計算モデルでは,混雑を緩和するストキャスティック細胞損失を復元した.
結論:
- 群集誘発の細胞デラミネーションは,成長変異に対して表皮をバッファリングする重要なメカニズムです.
- このプロセスは,組織発達の過程で,細胞が順調に詰め込まれることを保証します.
- 生細胞のデラミネーションは,上皮質の増殖を細胞の侵入と結びつけ,癌の初期段階への影響を及ぼします.
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