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Updated: May 6, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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乱れたペプチドセグメントのステレオ固有の結合は,BKチャネル不活性化を媒介する

Vivian Gonzalez-Perez1, Xu-Hui Zeng, Katie Henzler-Wildman

  • 1Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA.

Nature
|April 24, 2012
PubMed
まとめ

本質的に乱れたタンパク質セグメントは,イオンチャネル不活性化のような重要な機能を媒介する. この研究は,これらの重要な生物学的プロセスの基礎となる2つの異なる分子相互作用,ステレオスペシフィック結合と直接的オクラージョンを明らかにしています.

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