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Mechanistic Models: Overview of Compartment Models01:21

Mechanistic Models: Overview of Compartment Models

Mechanistic models, a category encompassing both physiological and compartmental modeling, differ from empirical models' approaches to incorporating known factors about the systems being modeled. Empirical models describe data with minimal assumptions, while mechanistic models aim to provide a robust description of available data by specifying assumptions and integrating known factors about the system. Compartmental analysis is a key example of a mechanistic model in pharmacokinetics and...
Rab Cascades01:25

Rab Cascades

Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.
Three-Compartment Open Model01:06

Three-Compartment Open Model

The three-compartment open model is a pharmacokinetic model used to describe the distribution and elimination of drugs following extravascular administration. It comprises a central compartment representing the plasma and two peripheral compartments. The highly perfused peripheral compartment represents organs and tissues with a rich blood supply, such as the liver, kidneys, and lungs. The scarcely perfused peripheral compartment represents tissues with lower blood supply, such as adipose...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Electron Transport Chain: Complex III and IV01:43

Electron Transport Chain: Complex III and IV

During the electron transport chain, electrons from NADH and FADH2 are first transferred to complexes I and II, respectively. These two complexes then transfer the electrons to ubiquinol, which carries them further to complex III. Complex III passes the electrons across the intermembrane space to Cyt c, which carries them further to complex IV. Complex IV donates electrons to oxygen and reduces it to water. As electrons pass through complexes I, III, and IV, the energy released aids the pumping...

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関連する実験動画

Updated: May 23, 2026

Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

3コンパートメントの化学的に駆動された分子情報ラッチ.

Armando Carlone1, Stephen M Goldup, Nathalie Lebrasseur

  • 1School of Chemistry, University of Edinburgh, UK.

Journal of the American Chemical Society
|April 25, 2012
PubMed
まとめ

この研究は,ロタキサン情報ラッチを導入します. チラルの触媒は,軌道に沿ったマクロサイクルの方向移動を制御し,分子輸送のための新しい方法を実証しました.

科学分野:

  • 超分子化学 超分子化学
  • 分子機械とは,分子機械のこと.
  • 有機化学 オーガニック・ケミストリー

背景:

  • ロタキサンは,軸にスレッドされたマクロサイクルを備えた分子組成です.
  • インフォメーションラチェットは,外部の刺激を利用して,分子レベルで方向運動を達成します.
  • 分子システムにおける方向輸送の制御は,高度な分子装置の開発に不可欠です.

研究 の 目的:

  • 3コンパートメントのロタキサン情報ラッチの設計と特徴付け.
  • 分子運動の方向制御のためのキラル触媒の使用を実証する.
  • マクロサイクルの輸送に触媒キラリティの影響を調査する.

主な方法:

  • 3つのコンパートメントのロタキサンシステムの合成.
  • キラル型4-ジメチラミノピリジン (DMAP) 基の触媒を用いる.
  • ベンゾイル化反応を用いてマクロサイクルの移位を誘導する.
  • 顕微鏡技術を用いてマクロサイクルの方向輸送を分析する.

主要な成果:

  • ロタキサン情報ラッチは,アキラル・トラックに沿ってマクロサイクルの方向輸送を可能にします.
  • チラルのDMAP触媒は,ベンゾイル化反応を効果的に促進する.

さらに関連する動画

Automated Protocols for Macromolecular Crystallization at the MRC Laboratory of Molecular Biology
11:20

Automated Protocols for Macromolecular Crystallization at the MRC Laboratory of Molecular Biology

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Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
11:55

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Published on: August 16, 2016

関連する実験動画

Last Updated: May 23, 2026

Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

Automated Protocols for Macromolecular Crystallization at the MRC Laboratory of Molecular Biology
11:20

Automated Protocols for Macromolecular Crystallization at the MRC Laboratory of Molecular Biology

Published on: January 24, 2018

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
11:55

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Published on: August 16, 2016

  • キラル触媒のハンドル性は,マクロサイクルが運ばれる主要なエンドコンパートメントを決定する.
  • 触媒のキラリティに基づいたマクロサイクルの主に一方的な動きを達成した.

    • 結論:

    • チラル触媒は,ロタキサン系における分子輸送の方向性を制御するために使用できます.
    • この研究は,触媒で制御された方向運動を持つ情報ラチェットの新しいアプローチを提示しています.
    • 開発されたシステムは,分子スイッチや論理ゲートにおけるアプリケーションの可能性を秘めています.