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Updated: Jun 30, 2026

Lentiviral-mediated Knockdown During Ex Vivo Erythropoiesis of Human Hematopoietic Stem Cells
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ラミノパシーについては,SUN1をダイヤルする

Yousin Suh1, Brian K Kennedy

  • 1Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Cell
|May 1, 2012
PubMed
まとめ

A型核ラミンの変異は,プロゲリアと筋縮を含む疾患のグループであるラミノパシーを引き起こす. 核内膜タンパク質であるSUN1の発現が増加すると,これらの状態で病理が引き起こされます.

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Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...