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Updated: May 22, 2026

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
10:10

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リプレッサー・グラデーションのシステムは,ビコイドに依存した標的遺伝子の境界を空間的に整理する

Hongtao Chen1, Zhe Xu, Constance Mei

  • 1Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA.

Cell
|May 1, 2012
PubMed
まとめ

抑制的グラデーションは,ビコイド活性化だけでなく,胚の発達における遺伝子境界を位置づけます. ペアルールタンパク質のRuntは,この抑圧システムにおいて鍵であり,ビコイド形態原モデルを精製しています.

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Cis-regulatory Sequences02:02

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Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form dimers that...
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Prokaryotic Transcriptional Activators and Repressors01:58

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The organization of prokaryotic genes in their genome is notably different from that of eukaryotes. Prokaryotic genes are organized, such that the genes for proteins involved in the same biochemical process or function are located together in groups. This group of genes, along with their regulatory elements, are collectively known as an operon. The functional genes in an operon are transcribed together to give a single strand of mRNA known as polycistronic mRNA.
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