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Updated: May 9, 2026

Analysis of Translation Initiation During Stress Conditions by Polysome Profiling
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mTORC1媒介によるmRNA翻訳の調節のための統一モデル

Carson C Thoreen1, Lynne Chantranupong, Heather R Keys

  • 1Department of Cancer Biology, Dana Farber Cancer Institute, 250 Longwood Avenue, Boston, Massachusetts 02115, USA.

Nature
|May 4, 2012
PubMed
まとめ

ラパミシン複合体1 (mTORC1) の哺乳類標的は,5'端オリゴピリミジン (TOP) モチーフを持つメッセンジャーRNA (mRNA) の翻訳を選択的に制御する. この調節は4E結合タンパク質 (4E-BPs) とeIF4G1によって媒介され,細胞成長に影響を与えます.

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