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統合失調症における再発予防のための抗精神病薬対プラセボ:体系的なレビューとメタ解析
Stefan Leucht1, Magdolna Tardy, Katja Komossa
1Department of Psychiatry and Psychotherapy, Technische Universität München, Klinikum rechts der Isar, Munich, Germany. stefan.leucht@lrz.tum.de
Lancet (London, England)
|May 8, 2012
まとめ
抗精神病薬は,プラセボと比較して,統合失調症患者の再発および再入院を大幅に減少させます. しかし,これらの利益は,体重増加や運動障害などの潜在的な副作用とバランスをとらなければなりません.
科学分野:
- 精神科医は精神病を患っている.
- 薬理学 薬理学とは
背景:
- 統合失調症の再発予防における抗精神病薬の有効性に関する体系的なレビューは不十分である.
- これまでの研究は,これらの治療法に関する論争を完全に解決していない.
研究 の 目的:
- 抗精神病薬と統合失調症患者の様々なアウトカムとの関連性を評価する.
- 統合失調症の治療における論争の的課題を解決するために.
主な方法:
- 複数のデータベース (Cochrane,PubMed,Embase) を検索し,製薬会社に連絡しました.
- 安定した統合失調症患者の抗精神病薬療法とプラセボを比較したランダム化試験を含む.
- 主なアウトカムは7〜12ヶ月間の再発であり,安全性および機能的アウトカムも検討されました.
主要な成果:
- 抗精神病薬は1年後に再発率 (27%対64%) と再入院率 (10%対26%) を著しく低下させた.
- 限られた証拠は,抗精神病薬による生活の質の向上と攻撃性の低下を示唆しています.
- プラセボと比較して,抗精神病薬で体重増加,運動障害,鎮静が観察されました.
結論:
- メンテナンス抗精神病薬の治療は,統合失調症の患者に有益です.
- 抗精神病薬の利点と副作用を比較する必要があります.
- 将来の研究は,社会参加の成果と長期的な罹病率/死亡率を調査すべきである.
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