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Updated: May 5, 2026

A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds
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Published on: April 6, 2016

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EGFRは不確定状態にある

Michael J Eck1, William C Hahn

  • 1Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. eck@red.dfci.harvard.edu

Cell
|May 15, 2012
PubMed
まとめ

エピデルマ・成長因子受容体 (EGFR) の腫瘍性変異は,乱れたキナーゼ状態を安定させ,異常な活性化につながるので,癌を促進します. この研究は,EGFR変異が構造的不安定性を通して癌を駆動する方法を明らかにしています.

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