抗癌薬の連続的な投与は,アポプトシス信号伝達ネットワークの再配線によって細胞死を促進する

Michael J Lee1, Albert S Ye, Alexandra K Gardino

  • 1Department of Biology, David H. Koch Institute for Integrative Cancer Research, Cambridge, MA 02139, USA.

Cell
|May 15, 2012
PubMed
まとめ

EGFRの抑制は時間的に段階的に行われ,同時に行われないが,トリプルネガティブな乳がん細胞を化学療法に敏感にする. このダイナミックな再配線は,細胞死経路を再活性化することで,がんを標的とする.

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