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Updated: May 6, 2026

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
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Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure

Published on: August 11, 2017

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腫瘍性突然変異はEGFRキナーゼの固有障害を逆転させ,受容体の二分化を促進する

Yibing Shan1, Michael P Eastwood, Xuewu Zhang

  • 1D.E. Shaw Research, New York, NY 10036, USA. yibing.shan@deshawresearch.com

Cell
|May 15, 2012
PubMed
まとめ

エピデルマ・成長因子受容体 (EGFR) 変異は,二分化を促進することによって癌を促進します. L834Rのような特定の突然変異はEGFRキナーゼ領域を安定させ,がんのシグナル伝達と潜在的薬物標的化につながる.

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Visualizing Genetic Variants, Short Targets, and Point Mutations in the Morphological Tissue Context with an RNA In Situ Hybridization Assay10:57

Visualizing Genetic Variants, Short Targets, and Point Mutations in the Morphological Tissue Context with an RNA In Situ Hybridization Assay

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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