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Updated: May 22, 2026

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
10:44

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage

Published on: January 31, 2018

ヒトのPARP-1によるDNA損傷依存型ポリ (ADP-リボシル化) の構造的基礎

Marie-France Langelier1, Jamie L Planck, Swati Roy

  • 1Department of Biochemistry and Molecular Biology, The Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Science (New York, N.Y.)
|May 15, 2012
PubMed
まとめ

DNA損傷によるPoly ((ADP-リボース) ポリメラーゼ-1 (PARP-1) 活性化には,崩壊したPARP-1ドメイン構造が含まれています. このDNA誘発によるコンフォームは,触媒ドメインを不安定化し,活性化のためのタンパク質のダイナミクスを増加させます.

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