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Updated: May 21, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Grp94阻害剤の開発について

Adam S Duerfeldt1, Laura B Peterson, Jason C Maynard

  • 1Department of Medicinal Chemistry, The University of Kansas, Lawrence, Kansas 66047, USA.

Journal of the American Chemical Society
|May 31, 2012
PubMed
まとめ

ターゲティングヒートショックタンパク質90 (Hsp90) は,がん治療の可能性を秘めています. 新しい阻害剤は,ERに定着するHsp90であるGrp94を選択的に標的にし,汎Hsp90阻害剤で見られる毒性効果を回避します.

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Eukaryotic Transcription Inhibitors01:52

Eukaryotic Transcription Inhibitors

Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a DNA...