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Updated: May 21, 2026

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction
11:02

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction

Published on: September 14, 2018

遺伝的にコードされた非自然なアミノ酸を用いた双特定抗体の合成

Chan Hyuk Kim1, Jun Y Axup, Anna Dubrovska

  • 1Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Journal of the American Chemical Society
|May 31, 2012
PubMed
まとめ

研究者らは,非自然なアミノ酸を用いて,がんを正確に標的にするための双特定抗体を設計した. この新しい方法は,強力なanti-HER2 / anti-CD3抗体を生成し,臨床前の細胞ターゲティングおよび細胞毒性研究で高い有効性を実証しました.

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Genetic Incorporation of Biosynthesized L-dihydroxyphenylalanine (DOPA) and Its Application to Protein Conjugation10:24

Genetic Incorporation of Biosynthesized L-dihydroxyphenylalanine (DOPA) and Its Application to Protein Conjugation

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