持続した静脈性心拍動と静脈細動は,STセグメントの上昇のない急性冠状動脈症候群を合併させる
Jonathan P Piccini1, Jennifer A White, Rajendra H Mehta
1Division of Cardiology, Duke Clinical Research Institute, Duke University Medical Center, PO Box 17969, Durham, NC 27705, USA. jonathan.piccini@duke.edu
Circulation
|May 31, 2012
まとめ
持続した心室性短心/心室細動 (VT/VF) はまれであるが,STセグメントの上昇のない急性冠状動脈症候群 (NSTE ACS) の後期に発生することがあります. この合併症は,死亡率を大幅に増加させ,不律性死亡の予防のための延長されたモニタリングと介入を必要とします.
科学分野:
- 心臓病学 心臓病学
- クリニカル・メディシン 臨床医学
- 内科内科は,内科の内科である.
背景:
- 心室不律症 (VT/VF) は,急性冠動脈症候群 (ACS) の致命的な合併症である.
- 非STセグメント上昇ACS (NSTE ACS) の持続性VT/VFの発生率と予後はよく記述されていません.
- この研究は,現代のNSTE ACS集団におけるVT/VFに関する知識のギャップに対処しています.
研究 の 目的:
- 持続した心房短拍/心房動 (VT/VF) の発生率を調べる.
- NSTE ACS患者のVT/VFに関連した予後と死亡率を評価する.
- アリズム不良による死亡を予防するための最適なモニタリング期間と潜在的な介入を決定する.
主な方法:
- NSTE ACS (EARLY ACS) の早期グリコプロテインIIb/IIIa阻害試験の9211人の患者の分析.
- VT / VFの累積的な発生率の検討,タイミングによって層分化 (登録後の≤48時間対>48時間).
- VT/VFの予測要因を特定し,30日死亡率と1年死亡率の評価.
主要な成果:
- VT/VFの累積的な発生率は1.5% (n=141) で,48時間以内に発生したのは0.6%,48時間後に発生したのは0.9%.
- VT/VFの患者では,心不全の発生率,低エジェクション分数 (<30%),三重血管冠動脈疾患の発生率が高かった.
- VT/VFは,30日および1年の死亡率を大幅に増加させ,遅発のVT/VF (>48時間) のリスクが高くなりました.
- 不律性死は,VT/VFを経験した患者でより頻繁であった (26.4%対6.9%).
結論:
- 持続的なVT/VFは,NSTE ACS後の最初の48時間以内に発生する可能性が,NSTE ACS後の48時間後に発生する可能性があります.
- 早期および遅期のVT/VFに関連したすべての原因による死亡率の大幅な増加は,拡張されたモニタリングの必要性を強調しています.
- アリズム不良による死亡を防ぐための介入は,VT/VFを経験しているNSTE ACS患者にとって極めて重要です.
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