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Updated: May 21, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
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FrizzledによるWnt認識の構造的根拠

Claudia Y Janda1, Deepa Waghray, Aron M Levin

  • 1Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.

Science (New York, N.Y.)
|June 2, 2012
PubMed
まとめ

Frizzled-8に結合したXenopus Wnt8の構造は,ユニークな2ドメインの"手"の形を明らかにしています. 脂質群と特定のアミノ酸を含むこの相互作用は,Wntシグナル伝達の複雑さを説明し,薬剤開発に役立ちます.

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Polarized Translocation of Fluorescent Proteins in Xenopus Ectoderm in Response to Wnt Signaling

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