Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
From DNA to Protein03:06

From DNA to Protein

The flow of genetic information in cells from DNA to mRNA to protein is described by the central dogma, which states that genes specify the sequence of mRNAs, which in turn specify the sequence of amino acids making up all proteins. The decoding of one molecule to another is performed by specific proteins and RNAs. Because the information stored in DNA is so central to cellular function, it makes intuitive sense that the cell would make mRNA copies of this information for protein synthesis...
Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA molecules by RNA...

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Deep learning of functional perturbations from condensate morphology.

Cell·2026
Same author

Ribosome biogenesis bottlenecks reveal vulnerabilities in cancer.

bioRxiv : the preprint server for biology·2026
Same author

Omega stabilizes RNA polymerase condensates and contributes to cellular fitness during acid stress.

bioRxiv : the preprint server for biology·2026
Same author

Ribosome Molecular Aging Shapes Translation Dynamics.

bioRxiv : the preprint server for biology·2026
Same author

Kinase KEY1 controls pyrenoid condensate size throughout the cell cycle by disrupting phase separation interactions.

Nature cell biology·2026
Same author

Metabolism of Epigenetic Ribonucleosides Leads to Nucleolar Stress and Cytotoxicity.

ACS chemical biology·2026

関連する実験動画

Updated: May 21, 2026

Combined Nucleotide and Protein Extractions in Caenorhabditis elegans
10:37

Combined Nucleotide and Protein Extractions in Caenorhabditis elegans

Published on: March 17, 2019

段階的にRNAとタンパク質を取得する.

Stephanie C Weber1, Clifford P Brangwynne

  • 1Princeton University, Department of Chemical and Biological Engineering, NJ 08544, USA.

Cell
|June 12, 2012
PubMed
まとめ

RNAの粒子は,膜に結合していない臓器細胞で,ダイナミックな滴を形成します. 最近の研究では,構造的特徴が,その組み立てを相変遷で駆動し,細胞組織に影響を与え,病気を引き起こす可能性があることを明らかにしています.

科学分野:

  • 細胞生物学 細胞生物学
  • バイオケミストリー バイオケミストリー
  • 分子生物学は分子生物学である.

背景:

  • RNAの粒のような非膜に結合した臓器細胞は,ダイナミックなドロップレットのような行動を示します.
  • これらの臓器細胞の組み立てを制御する正確な分子機構は,ほとんど未知のままです.
  • 粒子の形成を理解することは,細胞の組織と疾患の病原性を理解するために不可欠です.

研究 の 目的:

  • 膜に結合しない臓器細胞,特にRNA粒子の組み立ての基礎にある分子詳細を解明する.
  • これらの細胞区画の形成とダイナミクスを駆動する重要な構造的特徴を特定する.
  • 段階移行,細胞組織,および病的なタンパク質の集積の間のつながりを探求する.

主な方法:

  • RNA粒子の組立に関する最近の出版物の文献レビュー.
  • 臓器細胞形成に関連する構造的,生化学的データの分析.
  • 細胞組織における相変化の役割を調査する.

主要な成果:

  • 最近のいくつかの研究では,RNAの粒子の組み立てを促進する特定の構造的特徴を特定しています.
  • これらの特徴は,液体-液体相分離を通して,動的滴の形成を促進します.

さらに関連する動画

Studying RNA Interactors of Protein Kinase RNA-Activated during the Mammalian Cell Cycle
10:05

Studying RNA Interactors of Protein Kinase RNA-Activated during the Mammalian Cell Cycle

Published on: March 5, 2019

関連する実験動画

Last Updated: May 21, 2026

Combined Nucleotide and Protein Extractions in Caenorhabditis elegans
10:37

Combined Nucleotide and Protein Extractions in Caenorhabditis elegans

Published on: March 17, 2019

Studying RNA Interactors of Protein Kinase RNA-Activated during the Mammalian Cell Cycle
10:05

Studying RNA Interactors of Protein Kinase RNA-Activated during the Mammalian Cell Cycle

Published on: March 5, 2019

  • この発見は,相変化が細胞の構成要素を機能的に組織する方法を強調しています.
  • 結論:

    • RNAの粒子のような非膜に結合した臓器細胞の組み立ては,特定の構造要素によって引き起こされます.
    • フェーズトランジションは細胞の組織化において重要な役割を果たし,タンパク質の集積を含む疾患に関与することがあります.