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フルーツレスでは,2つの敵対的なクロマチンの因子を採用し,単一のニューロンの性二形態を確立します
Hiroki Ito1, Kosei Sato, Masayuki Koganezawa
1Division of Neurogenetics, Tohoku University Graduate School of Life Sciences, Sendai, Japan.
Cell
|June 12, 2012
まとめ
ドロソフィラの果実のない (fru) 遺伝子である.
科学分野:
- 神経科学は神経科学である.
- 遺伝学 遺伝学とは
- 発達生物学 発達生物学とは
背景:
- ドロソフィラ無果 (fruitless) 遺伝子は,男性の性行為と性二形性ニューロン回路の発達に不可欠である.
- フルーが神経細胞の性的運命を決定する正確な分子機構は,完全に理解されていません.
研究 の 目的:
- 果実のない (果実) 遺伝子が神経細胞の性的運命を決定するメカニズムを解明する.
- ニューロンの果実媒介性性分化に関与する分子プレーヤーを特定する.
主な方法:
- フルーツタンパク質と他の細胞因子の相互作用を研究した.
- フルーボン・コンプレックスによるクロマチン調節体の徴募を分析した.
- HDAC1とHP1aの発現を操作することで,神経細胞の性命に及ぼす影響を調べました.
主要な成果:
- フルーは,トランスクリプションのコファクターであるボーナス (Bon) と複合体を形成する.
- フルーボン複合体は,男性化のためにヒストン脱酸化酵素1 (HDAC1) または神経細胞の非男性化のためにヘテロクロマチンタンパク質1a (HP1a) を採用します.
- HDAC1またはHP1aレベルを変更すると,男性対女性の典型的なニューロンの割合が変化し,単一のニューロンレベルですべてまたは何もない性的運命の決定を示します.
結論:
- フルーボン複合体は,HDAC1とHP1aを利用して,個々のニューロンの性的運命を決定する中央スイッチとして機能します.
- 神経性命運の決定は,すべてまたは何もないプロセスであり,異性間の特徴のスペクトルではありません.
- この研究は,染色体修正剤によって調節される性特異性ニューロン発達の新しいメカニズムを明らかにしています.
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02:19The Y Chromosome Determines Maleness
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02:45The Ratio of X Chromosome to Autosomes
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02:50Dosage Compensation
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02:38Heterochromatin
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Constitutive heterochromatin: It is a highly compact region of chromatin that is mostly concentrated in the centromere and telomere. Unlike euchromatin, the amino acid at 9th...
Constitutive heterochromatin: It is a highly compact region of chromatin that is mostly concentrated in the centromere and telomere. Unlike euchromatin, the amino acid at 9th...