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Updated: May 21, 2026

The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions
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ニューデリーメタロβ-ラクトマゼ:β-ラクトームの認識と抑制に関する構造的洞察

Dustin T King1, Liam J Worrall, Robert Gruninger

  • 1Department of Biochemistry and Molecular Biology and Center for Blood Research, University of British Columbia, 2350 Health Sciences Mall, Vancouver, British Columbia, Canada V6T 1Z3.

Journal of the American Chemical Society
|June 21, 2012
PubMed
まとめ

ニューデリーのメタロ-β-ラクタマゼ-1 (NDM-1) 酵素は,重要なβ-ラクタム抗生物質に対する耐性を付与します. 構造分析は,NDM-1がカルバペネムおよび阻害剤とどのように相互作用するかを明らかにし,新しい薬の開発を導く.

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