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Updated: May 21, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates
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Published on: February 27, 2016

SIRT7は,H3K18の脱エチル化と,腫瘍性変異の維持を結びつけている

Matthew F Barber1, Eriko Michishita-Kioi, Yuanxin Xi

  • 1Department of Biology, Stanford University, Stanford, California 94305, USA.

Nature
|June 23, 2012
PubMed
まとめ

ヒストン脱酸化酵素であるSIRT7は,H3K18Ac.Ac.を脱酸化することによって癌細胞を安定させます. SIRT7を枯渇させると,腫瘍の成長が低下し,がんの進行におけるSIRT7の役割と,治療標的としての潜在力を強調する.

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