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パネス細胞ニッチのmTORC1は,腸の幹細胞機能とカロリー摂取を結びつけている

Ömer H Yilmaz1, Pekka Katajisto, Dudley W Lamming

  • 1Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.

Nature
|June 23, 2012
PubMed
まとめ

カロリー制限は,mTORC1シグナル伝達を通じてパネス細胞を調節することによって,腸の幹細胞機能を高めます. このプロセスは,Bst1と周期的なADPリボースを巻き込み,ニッチな領域を強調します.

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