関連する実験動画

Updated: May 21, 2026

A High-content Imaging Workflow to Study Grb2 Signaling Complexes by Expression Cloning
10:52

A High-content Imaging Workflow to Study Grb2 Signaling Complexes by Expression Cloning

Published on: October 30, 2012

基礎FGF受容体のシグナル伝達が二次元Grb2によって阻害される

Chi-Chuan Lin1, Fernando A Melo, Ragini Ghosh

  • 1Department of Biochemistry and Molecular Biology and Center for Biomolecular Structure and Function, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Cell
|June 26, 2012
PubMed
まとめ

アダプタータンパク質Grb2は,線維細胞成長因子受容体2 (FGFR2) の活性を活性的に調節する. Grb2がFGFR2と結合すると,最初は完全な受容体活性化が妨げられ,これは刺激とGrb2のフォスフォリレーションによってのみ達成される.

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