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Updated: May 5, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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p53はミトコンドリアの透過性移行孔を開けて,ネクロシスを引き起こす

Angelina V Vaseva1, Natalie D Marchenko, Kyungmin Ji

  • 1Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA.

Cell
|June 26, 2012
PubMed
まとめ

この研究では,p53タンパク質は,ミトコンドリア内のサイクロフィリンDと相互作用することで,酸化ストレス中に死滅を引き起こすことが明らかになりました. この相互作用を遮断すると,脳卒中から保護され,イシュケミアの新しい治療標的を強調します.

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