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MDM2-p53阻害剤AM-8553の迅速な合成が示されました

Brian S Lucas1, Benjamin Fisher, Lawrence R McGee

  • 1Department of Medicinal Chemistry, Amgen, Inc., S. San Francisco, California 94080, United States. blucas@amgen.com

Journal of the American Chemical Society
|June 28, 2012
PubMed
まとめ

複合的なMDM2/p53阻害剤AM-8553の新しい合成経路により,収穫量が著しく改善されました. この最適化されたプロセスは,効率的な薬剤開発のために高度な化学反応を利用しています.

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