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Updated: May 5, 2026

Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications
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Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications

Published on: January 27, 2014

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Ca(2+) -刺激されたアデニリルサイクラゼAC1は,単一の遺伝子療法として,およびHCN2と組み合わせて,効率的な生物学的なペースを発生します

Gerard J J Boink1, Bruce D Nearing, Iryna N Shlapakova

  • 1Department of Pharmacology, Center for Molecular Therapeutics, Columbia University, New York, NY 10032, USA.

Circulation
|July 4, 2012
PubMed
まとめ

心臓内のAC1またはHCN2/AC1を用いた遺伝子治療は,HCN2単独と比較して優れた生物ペースと自律的応答性を提供します. この進歩は,心拍のコントロールと適応力を改善します.

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