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Updated: May 20, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
09:08

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

Published on: January 13, 2017

マルレイラクトン (Malleilactone),ポリケチド合成酵素由来の毒性因子で,Burkholderia pseudomallei群の病原体の暗号的二次代謝体によってコードされています

John B Biggins1, Melinda A Ternei, Sean F Brady

  • 1Laboratory of Genetically Encoded Small Molecules, The Rockefeller University and Howard Hughes Medical Institute, 1230 York Avenue, New York, New York 10068, USA.

Journal of the American Chemical Society
|July 7, 2012
PubMed
まとめ

研究者らは,バークホルディア菌の病原体の中で,マルレイラクトンと呼ばれる毒素を生成する静かな遺伝子群を発見した. このクラスタを活性化すると,バクテリアが弱くなり,メリオイドーシスと腺炎の治療標的としてマルレイラクトンが示唆された.

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Total Protein Extraction and 2-D Gel Electrophoresis Methods for Burkholderia Species08:31

Total Protein Extraction and 2-D Gel Electrophoresis Methods for Burkholderia Species

Published on: October 15, 2013

Transposon-insertion Sequencing as a Tool to Elucidate Bacterial Colonization Factors in a Burkholderia gladioli Symbiont of Lagria villosa Beetles09:55

Transposon-insertion Sequencing as a Tool to Elucidate Bacterial Colonization Factors in a Burkholderia gladioli Symbiont of Lagria villosa Beetles

Published on: August 12, 2021

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