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Updated: May 20, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
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(R) メレインの合成は,部分的に還元するイテラティブポリケチド合成酵素による

Huihua Sun1, Chun Loong Ho, Feiqing Ding

  • 1School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551.

Journal of the American Chemical Society
|July 17, 2012
PubMed
まとめ

メレインのバイオシンセシスは,ペンタケチドを生成する反復ポリケチド合成酵素 (PR-PKS) を部分的に減少させることを含む. この酵素のケトリデクタゼドメインは,ケト還元を独占的に制御し,天然製品におけるプログラムされた合成を説明します.

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