腸内微生物群の構成は,高齢者の食事と健康と相関しています
Marcus J Claesson1, Ian B Jeffery, Susana Conde
1Department of Microbiology, University College Cork, Ireland.
Nature
|July 17, 2012
まとめ
高齢者の食事と腸内微生物群の構成は,健康状態と脆弱性に関連しています. 食事や生活状況の影響を受けた微生物群の多様性の変化は,高齢化に関連する健康の低下と相関しています.
科学分野:
- ゲロントロジーはゲロントロジーの学科です.
- 微生物学 微生物学とは
- 栄養科学とは,栄養科学である.
背景:
- 腸内微生物群の変化は,肥満や炎症性疾患などの慢性疾患に関連しています.
- 高齢者は,若年成人と比較して,腸内微生物群の個体間多様性が大きい.
研究 の 目的:
- 高齢者における糞便の微生物群の構成,生活状況,食事,健康状態との関係を調査する.
- 微生物群の多様性と構成が,老化における脆弱性,共病性,栄養状態,炎症,糞便の代謝物とどのように相関するかを調査する.
主な方法:
- 178人の高齢者の糞便の微生物群組成の分析,居住地 (コミュニティ,デイホスピタル,リハビリテーション,長期介護) と食事パターンに基づいて.
- 微生物群のグループ化と,脆弱性,共病性,栄養状態,炎症マーカー,糞便水の代謝物質の測定値との相関.
主要な成果:
- 糞便の微生物群の組成は,居住場所と食事によってグループ化され,明確なグループ化が観察されました.
- 微生物群の組成は,脆弱性,共病性,栄養状態,炎症,糞便の代謝物と有意に相関していた.
- 長期介護を受けた個人は,コミュニティの住民と比較して微生物群の多様性が著しく低下し,コミュニティに関連した微生物群の喪失は,脆弱性の増加と相関していました.
結論:
- ダイエット,腸内微生物群,高齢者の健康状態との間には強い関係がある.
- 腸内微生物群の食事による変化は,老化過程で健康が低下する変化の速さに関与する.
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