自発的な冠動脈解剖の臨床的特徴,管理,および予後
Marysia S Tweet1, Sharonne N Hayes, Sridevi R Pitta
1Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA.
Circulation
|July 18, 2012
まとめ
自発性冠動脈解剖 (SCAD) は主に若い女性に影響を与え,しばしば心臓発作として現れる. 長期的なリスクには,再発および主要な心疾患不良事件が含まれ,継続的な患者のモニタリングの必要性を強調しています.
科学分野:
- 心臓病学 心臓病学
- 血管医学 血管医学とは
- 公衆衛生は公衆衛生である.
背景:
- 自発冠動脈解剖 (SCAD) は,原因が不明な急性冠動脈症候群である.
- SCADの臨床表現と長期的な予後については,さらなる特徴づけが必要である.
研究 の 目的:
- SCADの発生率,臨床的特徴,アウトカムを評価する.
- SCADに関連する病院内および長期のリスクを評価する.
- 潜在的に寄与する要因と,線維筋不形成症のような関連疾患を調査する.
主な方法:
- 血管検査でSCADが確認された87人の患者による単一センターコホート研究.
- 患者の人口統計,臨床表現,治療戦略,入院イベントの評価.
- SCAD再発および主要な不良心事 (MACE) の長期追跡調査.
主要な成果:
- SCADは主に若い人 (平均年齢42.6歳) に影響し,82%が女性です.
- 極端な運動は男性においてより一般的なトリガーであったが,産後状態は女性の18%で認められた.
- ST上昇心筋梗塞は49%の症例で,多血管性SCADは23%で発生しました.
- 保守的な管理と冠動脈バイパス移植は,入院コースを複雑にしていない.
- 皮膚経冠動脈介入 (PCI) は,技術的な障害の35%と1人の死亡と関連していました.
- SCAD再発は,平均47ヶ月のフォローアップ期間中に15人の女性患者で発生しました.
- 推定10年MACE率は47%であった.
- 線維筋不形成症は,動脈血管図の50%と,大動脈解剖の2人の患者で偶然に見つかりました.
結論:
- SCADは,若い,主に女性の人口集団に影響を与え,しばしばST上昇心筋梗塞として提示します.
- 病院での死亡率は低いが,PCIには重大な合併症のリスクがある.
- SCAD再発率が高いことと長期にわたるMACEは,患者の密接なフォローアップを必要とします.
- 線維筋硬化症は,SCADにおける新しい関連性および潜在的な原因因子です.
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