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Updated: May 20, 2026

TGF-β-mediated Endothelial to Mesenchymal Transition (EndMT) and the Functional Assessment of EndMT Effectors using CRISPR/Cas9 Gene Editing
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TGF-β-mediated Endothelial to Mesenchymal Transition (EndMT) and the Functional Assessment of EndMT Effectors using CRISPR/Cas9 Gene Editing

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TNF受容体1の遺伝的リスクは,多発性硬化症における抗TNF療法の結果を反映しています

Adam P Gregory1, Calliope A Dendrou2, Kathrine E Attfield2

  • 1MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.

Nature
|July 18, 2012
PubMed
まとめ

全ゲノム関連研究により,多発性硬化症 (MS) に関連した遺伝子変異体 rs1800693 が特定されました. TNFRSF1A遺伝子のこの変異は,腫瘍死滅因子受容体1 (TNFR1) の溶解可能な形態を生み出し,他の自己免疫疾患で使用されるTNF阻害剤を模倣します.

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