関連する実験動画

Updated: May 20, 2026

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
10:29

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Published on: May 9, 2025

HIVには親指を下に:NNRTIに結合したHIV-1逆転写酵素でドメインレベルの再編成が起こります

David W Wright1, S Kashif Sadiq, Gianni De Fabritiis

  • 1Centre for Computational Science, Department of Chemistry, University College London , London WC1H 0AJ, U.K.

Journal of the American Chemical Society
|July 26, 2012
PubMed
まとめ

非核糖逆転写酵素阻害剤 (NNRTIs) は,オープン状態のHIV-1 RTを完全にロックしません. シミュレーションにより,薬剤結合酵素は,開いた形状と閉じた形状の分布で存在し,移行運動を変化させることが明らかになりました.

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Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors05:46

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

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Determining 3'-Termini and Sequences of Nascent Single-Stranded Viral DNA Molecules during HIV-1 Reverse Transcription in Infected Cells13:07

Determining 3'-Termini and Sequences of Nascent Single-Stranded Viral DNA Molecules during HIV-1 Reverse Transcription in Infected Cells

Published on: January 30, 2019

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