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設計者のブレオミシンは,DNAの分裂活動を大幅に改善しました

Sheng-Xiong Huang1, Zhiyang Feng, Liyan Wang

  • 1Department of Chemistry, The Scripps Research Institute, Jupiter, Florida 33458, USA.

Journal of the American Chemical Society
|July 27, 2012
PubMed
まとめ

エンジニアリングされたブレオミシン (BLM) アナログは,がん治療において有望であることが示されています. 新型6'-デオキシ-BLM Zは強力なDNA分裂活性を示しており,化学療法における肺毒性の低下の可能性を示唆しています.

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Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
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