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関連する概念動画

Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Riboswitches01:56

Riboswitches

Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Position-effect Variegation02:32

Position-effect Variegation

In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
Nucleosome Remodeling02:54

Nucleosome Remodeling

Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...

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関連する実験動画

Updated: May 20, 2026

Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

機械電子DNAスイッチ

Jason M Thomas1, Hua-Zhong Yu, Dipankar Sen

  • 1Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6.

Journal of the American Chemical Society
|July 28, 2012
PubMed
まとめ
この要約は機械生成です。

私たちは,水銀イオン (Hg2+) を使用して,機械的な動きとDNA電荷輸送を制御する新しいDNAナノマシンを開発しました. この水銀で活性化されたDNAスイッチは,物理的な動きと電子信号をリンクし,新しいナノデバイス監視機能を可能にします.

さらに関連する動画

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks
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Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

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Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

関連する実験動画

Last Updated: May 20, 2026

Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks
07:50

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

Published on: November 25, 2015

Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

科学分野:

  • * ナノテクノロジー
  • * 分子生物学 * 分子生物学
  • * バイオフィジックス

背景:

  • *DNAナノマシンは,ナノスケールデバイスの可能性を秘めています.
  • *DNAナノ構造の機械運動と電子特性を制御することは,重要な課題です.

研究 の 目的:

  • * メカニカルモーションを組み合わせて,水銀イオンを使って輸送を充電するDNAナノマシンを設計する.
  • * 電子的に監視できるDNAベースのメカノ電子スイッチの実証.

主な方法:

  • *水銀結合ドメインを備えた3方向の螺旋接合DNAナノマシンの構築.
  • * 化学的フットプリントとグアニン酸化測定法で,電荷輸送を監視する.
  • * 機械的な動きを追跡するためのフォースター共鳴エネルギー転送 (FRET).

主要な成果:

  • * T-T不一致に結合する水銀 (Hg2+) は,T-Hg2+-T塩基対を形成し,電荷輸送を大幅に改善しました.
  • *Hg2+結合/解離は,DNA幹の機械的動きと直接相関しています.
  • * 充電輸送の強化は,幹が曲がった形から線形,同軸で積み重ねられた形状に移動することと関連していました.

結論:

  • *新型のDNAナノマシンが作成され,水銀結合を機械的運動と変化した電荷輸送に変換しました.
  • * この水銀活性化DNAスイッチは,電子測定を介してナノデバイスの機械的な働きをモニタリングするためのパラダイムを提供します.