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Updated: May 20, 2026

Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyl(tropone)iron
07:56

Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyl(tropone)iron

Published on: August 12, 2019

クロストリエナミンは,非対称的有機触媒の有機触媒で

Kim Søholm Halskov1, Tore Kiilerich Johansen, Rebecca L Davis

  • 1Center for Catalysis, Department of Chemistry, Aarhus University , DK-8000 Aarhus C, Denmark.

Journal of the American Chemical Society
|July 28, 2012
PubMed
まとめ

新しい交叉結合トリエナミンは,高度にエナンチオセレクティブのダイエルス・アルダー反応と添加反応を可能にします. このオルガノカタリシスアプローチは,機能化されたバイサイクロ[2.2.2]オクタン化合物と,高い選択性を持つ γ′添加製品を生成します.

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The Hofmann and Curtius rearrangement reactions can be applied to synthesize primary amines from carboxylic acid derivatives such as amides and acyl azides. In the Hofmann rearrangement, a primary amide undergoes deprotonation in the presence of a base, followed by halogenation to generate an N-haloamide. A second proton abstraction produces a stabilized anionic species, which rearranges to an isocyanate intermediate via an alkyl group migration from the carbonyl carbon to the neighboring...
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