Myocardial Notchシグナリングは,心筋細胞を伝導性型のフェノタイプに再プログラムします
Stacey Rentschler1, Alberta H Yen, Jia Lu
1Cardiovascular Institute, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104, USA. srentsch@dom.wustl.edu
Circulation
|July 28, 2012
まとめ
ノッチ・シグナリングは心臓細胞の発達を誘導し,心臓細胞の祖先に特殊な伝導細胞になるよう指示します. この発見は,心臓血管組織を工学するために有望である.
科学分野:
- 心血管生物学 心血管生物学
- 発達生物学 発達生物学とは
- 細胞シグナル伝達 細胞信号伝達
背景:
- ノッチ・シグナリングは,細胞の運命を調節し,種間の心臓形成における分化を行います.
- 導電細胞への心筋細胞の漸進的な系統制限におけるその役割は未知のものである.
研究 の 目的:
- 心筋細胞の専門化におけるノッチ信号の役割を調査する.
- ノッチが心臓の原始細胞を伝導細胞の運命に導くことができるかどうかを判断するために.
主な方法:
- 発達初期に心筋内におけるNotch信号の活性化.
- 新生児の心筋細胞におけるノッチの試験管内活性化.
- トランスクリプトーム分析と電気生理学的評価.
主要な成果:
- アクティベーションされたNotchシグナリングは,心臓の伝導性のようなフェノタイプを促進します.
- 導電系特異的な遺伝子の子宮外発現が観察されました.
- 実験室内試験では,全線トランスクリプトームの変化とアクションポテンシャル特性の変化が示され,再プログラミングが示唆された.
結論:
- ノッチ・シグナリングは,室内心臓の祖先細胞に,導電性細胞に微分化するように指示することができます.
- 末期の心筋細胞は,可塑性を保持しており,心臓血管組織工学の可能性を示唆しています.
さらに関連する動画
関連する概念動画
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
01:30Cardiac Action Potential
Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
01:19Electrophysiology of Normal Cardiac Rhythm
The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase of...
01:28Mechanism of Cardiac Arrhythmias
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.