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Updated: May 19, 2026

Nuclear Magnetic Resonance Spectroscopy for the Identification of Multiple Phosphorylations of Intrinsically Disordered Proteins
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Nuclear Magnetic Resonance Spectroscopy for the Identification of Multiple Phosphorylations of Intrinsically Disordered Proteins

Published on: December 27, 2016

固体状態のNMRによって明らかにされたタウペア状の螺旋状フィラメントのβ-シートコア

Venita Daebel1, Subashchandrabose Chinnathambi, Jacek Biernat

  • 1NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.

Journal of the American Chemical Society
|August 7, 2012
PubMed
まとめ

研究者らは,固体NMRを用いて,アルツハイマー病におけるタウタンパク質繊維の原子構造を明らかにした. この研究では,タウの集積に不可欠なペアリングされた螺旋状フィラメント (PHF) の硬いコアが特定されました.

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