ホストの腸内微生物群の改造と,妊娠中の代謝の変化
Omry Koren1, Julia K Goodrich, Tyler C Cullender
1Department of Microbiology, Cornell University, Ithaca, NY 14853, USA.
Cell
|August 7, 2012
まとめ
妊娠は腸内細菌を変化させ,炎症を増加させ,第3 trimesterまでにエネルギー損失の兆候を増加させます. この変化した微生物群は,マウスに移植されると,肥満とインスリン不敏感性の増加を引き起こし,宿主の代謝における役割を示唆しました.
科学分野:
- 微生物学 微生物学とは
- 免疫学 免疫学とは
- メタボリック・ヘルス (代謝の健康)
背景:
- 妊娠は,メタボリックシンドロームと免疫および代謝の変化を共有しています.
- 腸内微生物群は,妊娠していない個人に代謝症候群の症状を誘発することができます.
研究 の 目的:
- 妊娠中の腸内微生物群の役割を調査する.
- 妊婦と乳児の糞便細菌を特徴付けるために.
主な方法:
- 91人の妊婦とその乳児の糞便細菌を分析した.
- 微生物群の構成と多様性は,三半期 (T1とT3) 間で比較されました.
- T1とT3の微生物群は,代謝の影響を評価するために,細菌のないマウスに移送されました.
主要な成果:
- 腸内微生物群の組成は,第1〜第3トリメスターから大きく変化した.
- 第3 trimesterの微生物群は,プロテオバクテリアとアクティノバクテリアの増加,富の減少,炎症とエネルギー損失の兆候を示しました.
- マウスに第3 trimesterの微生物群の移転は,第1 trimesterの微生物群と比較して,より大きな肥満とインスリン無感をもたらしました.
結論:
- 妊娠中の宿主-微生物の相互作用は,宿主の代謝に大きな影響を与えます.
- 妊娠中の腸内微生物群の変化は,代謝の変化に寄与する可能性があります.
- これらの宿主-微生物の相互作用は,妊娠中に有益である可能性があります.
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