シナプスおよびエクストラシナプスNMDA受容体は,異なる内生性コアゴニストによってゲートされます
Thomas Papouin1, Laurent Ladépêche, Jérôme Ruel
1INSERM U862, Neurocentre Magendie, 33077 Bordeaux, France.
Cell
|August 7, 2012
まとめ
異なるコアゴニストであるd-セリンとグリシンは,シナプスおよびエクストラシナプスN-メチル-d-アスパラテート受容体 (NMDARs) を選択的に活性化し,記憶や神経毒性などの脳機能に影響を与えます.
科学分野:
- 神経科学は神経科学である.
- 分子生物学は分子生物学である.
- 細胞生理学 細胞生理学
背景:
- N-メチル-d-アスパラテート受容体 (NMDARs) は,シナプスおよびエクストラシナプス部位に存在し,神経機能に不可欠です.
- 特定のコアゴニストとそのNMDAR活性化における役割は,まだ完全に理解されていません.
研究 の 目的:
- シナプスおよびエクストラシナプスNMDARの固有の内生性コアゴニストを特定する.
- NMDARの活動と脳プロセスに対するコアゴニスト分離の機能的影響を明らかにする.
主な方法:
- シナプス対エクストラシナプスNMDARsのためのコアゴニスト結合親和性を調査しました.
- NMDARの表面取引に対するd-セリンとグリシンの影響を分析した.
- 異なるNMDAR集団の長期的な増強,長期的なうつ,神経毒性における役割を調べた.
主要な成果:
- シナプティックなNMDARは優先的にd-セリンによって活性化され,エクストラシナプティックなNMDARはグリシンを利用する.
- 両方のコアゴニストは,サブユニットに依存した方法で,NMDARの表面取引を調節する.
- シナプス性NMDARは長期の増強とNMDA誘発の神経毒性を媒介するが,長期のうつ病は両方の受容体集団を巻き込む.
結論:
- NMDARの機能は,特定のコアゴニストと受容体の位置に決定的に依存しています.
- この分離は,脳機能におけるシナプスおよびエクストラシナプスNMDARの異なる生理学的および病理学的役割に関する新しい洞察を提供します.
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