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Updated: May 19, 2026

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
05:37

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

Published on: April 4, 2025

ヒトの血小板由来成長因子受容体βプロモーターで形成される主要なG-四重複体は,K+溶液で新しい断片鎖構造を採用する

Yuwei Chen1, Prashansa Agrawal, Robert V Brown

  • 1Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 1703 East Mabel Street, Tucson, Arizona 85721, USA.

Journal of the American Chemical Society
|August 8, 2012
PubMed
まとめ

研究者らは,血小板由来成長因子受容体β (PDGFR-β) 遺伝子プロモーターに新しいDNAG四重複構造を特定した. 壊れたG鎖を持つこのユニークな構造は,PDGFR-β関連がんおよび線維性疾患の治療薬の開発に新しいターゲットを提供します.

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A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase111:25

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