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体重状態と死亡率の関連性は,インシデント糖尿病の成人の死亡率と関連しています
Mercedes R Carnethon1, Peter John D De Chavez, Mary L Biggs
1Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N Lake Shore Dr, Ste 1400, Chicago, IL 60611, USA. carnethon@northwestern.edu
JAMA
|August 9, 2012
まとめ
新たに発症した2型糖尿病の正常体重の成人は,より高い死亡リスクに直面します. この研究では,正常なボディマス指数 (BMI) の個人は,体重過多または肥満の個人に比べて,全身,心血管,心血管以外の死亡率が増加したことを発見しました.
科学分野:
- 内分泌学と新陳代謝について
- エピデミオロジー エピデミオロジー
- 公共衛生は公衆衛生である.
背景:
- 代謝的に肥満の正常体重フェノタイプと呼ばれる正常体重の成人の2型糖尿病の死亡率は不明である.
- 糖尿病の診断時の体重状態による死亡率の影響を理解することは,臨床管理と公衆衛生戦略にとって極めて重要です.
研究 の 目的:
- 2型糖尿病と新たに診断された成人の体重状態と死亡率の関連性を調査する.
- 糖尿病の持続時間や意図的な体重減少などの混同要因を最小限に抑えるため,糖尿病の発生例に焦点を当てます.
主な方法:
- 発生糖尿病の2600人以上の参加者を含む5つの大規模な縦断的なコホート研究のプール分析.
- 参加者は,糖尿病の診断時に正常体重 (BMI 18.5-24.99) または過体重/肥満 (BMI ≥25) として分類されました.
- 死亡率のアウトカム (総死亡率,心血管疾患,心血管疾患以外の疾患) は,フォローアップ期間の中央値で追跡された.
主要な成果:
- 正常体重の個人は,インシデント糖尿病の成人の約12%を占める.
- 総,心血管,心血管以外の原因による死亡率は,体重が正常な参加者において,体重過多/肥満の参加者と比較して,著しく高かった.
- 調整されたハザード比は,発症糖尿病の正常体重の個体において,全死亡率および非心血管疾患による死亡率のリスクを大幅に増加させたことを示した.
結論:
- 2型糖尿病の診断時の正常体重は,全因および因果特定の死亡率の増加と関連しています.
- 発見は,正常体重が糖尿病患者の不良死亡結果から保護するものではないことを強調しています.
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