関連する実験動画
糖尿病と高血圧:悪い仲間たち
Ele Ferrannini1, William C Cushman
1Department of Internal Medicine, University of Pisa, Pisa, Italy. ferranni@ifc.cnr.it
Lancet (London, England)
|August 14, 2012
まとめ
高血圧は2型糖尿病において一般的であり,高血糖症に関連しています. 血圧のコントロールは,糖尿病患者の心血管疾患のリスクを低減するために非常に重要です.
科学分野:
- エンドクリノロジー エンドクリノロジー
- 心血管医学 心血管医学
- ネフロロジーは腎臓科です.
背景:
- 2型糖尿病患者の3分の2以上が高血圧である.
- 糖尿病における高血圧は,心血管疾患のリスクを大幅に高めます.
- 高血糖症と高血圧は,共通の病理生理学的経路を共有しています.
研究 の 目的:
- 2型糖尿病と高血圧を結びつける病理生理学的メカニズムを探求する.
- 糖尿病患者のための治療的血圧目標を設定する.
- 糖尿病患者に対して最適な抗高血圧戦略を推奨する.
主な方法:
- 糖尿病と高血圧を結びつける病理生理学的メカニズムのレビュー.
- 血圧目標に対する臨床試験の証拠の分析.
- 抗高血圧薬のクラスとその効果の評価.
主要な成果:
- 可能性のあるメカニズムには,インスリン抵抗性,高インスリン血症の効果,および高血糖症がレニン-アニオテンシン-アルドステロン系に与える影響が含まれます.
- 2型糖尿病患者には140/85mmHg未満の血圧目標値が推奨されています.
- シアジド利尿剤を併用したレニン=アニオテンシン系阻害剤は,優先される初期療法かもしれません.
- 抗高血圧薬は,一般的に,グルコース代謝に対する負の影響を上回る陽性な心臓血管の利点を示しています.
結論:
- 糖尿病,高血糖症,高血圧の相互作用を理解することが鍵となる.
- 積極的な血圧管理は,2型糖尿病における心血管の保護に不可欠です.
- 特定の抗高血圧剤の組み合わせは,管理可能な代謝効果を持つ効果的な血圧制御を提供します.
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