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男性の避妊のためのBRDTの小分子阻害

Martin M Matzuk1, Michael R McKeown, Panagis Filippakopoulos

  • 1Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA. mmatzuk@bcm.edu

Cell
|August 21, 2012
PubMed
まとめ

新しい男性避妊薬であるJQ1は,精子生産に不可欠なブロモドメインとエクストラトミナル (BET) タンパク質を標的にします. この可逆性阻害剤は精子数と運動性を減少させ,男性の避妊に有望なアプローチを提供します.

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